期刊文献+

试述单核苷酸多态性的研究进展 被引量:3

Advances in the Research of Single Nucleotide Polymorphism
在线阅读 下载PDF
导出
摘要 单核苷酸多态性(SNPs)是基因组织中最常见的一种遗传模式。文章在对人类基因组中SNPs的概念做简要说明的基础上,介绍了SNPs的检测、分析技术和方法,以及应用前景。 Single nucleotide polymorphisms (SNPs) are one of the most common models of genetic variant in human genome. Based on summarizing the SNPs of human genome, the techniques and methods of detection and analysis for SNPs were reviewed, and the prospects of application for SNPs were briefly introduced.
出处 《云南师范大学学报(自然科学版)》 2007年第6期40-44,共5页 Journal of Yunnan Normal University:Natural Sciences Edition
关键词 单核苷酸多态性 研究方法 应用 Single nucleotide polymorphism Method Application
  • 相关文献

参考文献33

  • 1饶子和.近期国外重要的生命科学研究计划和资助情况[J].中国科学基金,2006,20(5):272-277. 被引量:4
  • 2Venter J C,Adams M D,Myers E W,et al.The sequence of human genome[J].Science,2001,291(5507):1304-1351.
  • 3Rubin G M.Comparing species[J].Nature,2001,409:820-821.
  • 4International Human genome Sequencing Consortium.Initial sequencing and analysis of the human genome[J].Nature,2001,409:860-863.
  • 5The International SNP Map Working Group.A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms[J].Nature,2001,409:928 -933.
  • 6Satta Y,Li Y J,Takahata N.The neutral theory and natural selection in the HLA region[J].Front Biosci,1998,27:459-467.
  • 7Lee S T,Park S K,et al.A non-radioactive method for simultaneous detection of single-strand conformation polymorphisms (SSCPs) and heterroduplexes[J].Mol Cells,1995,5:668 -672.
  • 8Lyamichev V,Mast A L,et al.Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes[J].Nat Biotechnol,1999,17:292-290.
  • 9Cha R S,Zarbl H,Keohavong P,Thilly W G.Mismachtch amplification mutation assay (MAMA)[J].PCR Method Appl,1992,2 (1):14 -20.
  • 10Jobs M,Howell W M,et al.DASH-2:low-cost and high-throughput SNP genotyping by dynamic allele-specific hybridization on membrane arrays[J].Genome Res,2003,13:916-924.

二级参考文献117

共引文献16

同被引文献25

  • 1李代蓉,周清华,袁天柱,郭占林,朱文,王艳萍,陈晓禾,冯志华,车国卫.GSTM1和CYP2E1基因多态性与肺癌遗传易感性关系的研究[J].中国肺癌杂志,2005,8(1):14-19. 被引量:17
  • 2李健强,邵国光,刘琳琳,郑永晨.p53基因BstUⅠ位点多态性与非小细胞肺癌易感性及放射敏感性的相关性研究[J].中国肺癌杂志,2006,9(2):173-176. 被引量:7
  • 3吴冬,欧俊,惠宁.铂类化疗药耐药机制的分子基础及新观点[J].国际肿瘤学杂志,2006,33(4):256-258. 被引量:2
  • 4Risch NJ.Searching for genetic determinants in the new millennium[J].Nature,2000,405(6788):847-856.
  • 5Takayama S,Sato T,Krajewski S,et al.Cloning and functional analysis of BAG-1:a novel Bcl-2-binding protein with anti-cell death activity[J].Cell,1995,80(2):279-284.
  • 6Townsend PA,Stephanou A,Packham G,et al.BAG-1:a multi-functional pro-survival molecule[J].Int J Biochem Cell Biol,2005,37(2):251-259.
  • 7Sharp A,Cutress RI,Johnson PW,et al.Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth[J].FEBS Lett,2009,583(21):3405-3411.
  • 8Townsend PA,Cutress RI,Sharp A,et al.BAG-1:a multifunctional regulator of cell growth and survival[J].Biochim Biophys Acta,2003,1603(2):83-98.
  • 9Dobbyn HC,Hill K,Hamilton TL,et al.Regulation of BAG-1IRES-mediated translation following chemotoxic stress[J].Oncogene,2008,27(8):1167-1174.
  • 10Liu H,Liang Y,Li Y,et al.Gene silencing of BAG-1 modulates apoptotic genes and sensitizes lung cancer cell lines to cisplatin-induced apoptosis[J].Cancer Biol Ther,2010,9(10):832-840.

引证文献3

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部