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冠心病患者冠状动脉循环妊娠相关血浆蛋白-A及胰岛素样生长因子-I水平的变化

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摘要 [目的]探讨冠心病患者冠状动脉循环妊娠相关血浆蛋白A(PAPP-A)水平的变化及其机制。[方法]48例冠心病患者,其中稳定型心绞痛组24例,急性冠脉综合征组24例,及对照组10例,分别检测其冠状静脉窦和主动脉根部的PAPP-A水平和胰岛素样生长因子I(IGF-I)水平。[结果]在冠状静脉窦和主动脉根部,急性冠脉综合征组PAPP-A水平明显高于稳定型心绞痛组和对照组(P<0.01),而对照组IGF-I水平则高于前两组(P<0.05)。急性冠脉综合征组冠状静脉窦处PAPP-A水平明显高于主动脉根部处的PAPP-A水平(P<0.01)。[结论]冠状动脉循环PAPP-A的浓度差可作反映冠状动脉斑块稳定程度。
作者 梅卫义 杜志民 胡承恒 伍贵富 李怡 罗初凡 陈国伟
机构地区 中山大学附属第一医院心内科
出处 《中山大学学报（医学科学版）》 CAS CSCD 北大核心 2007年第B06期41-43,共3页 Journal of Sun Yat-Sen University:Medical Sciences
关键词 冠状动脉粥样硬化疾病 胰岛素样生长因子I 妊娠相关血浆蛋白A 斑块稳定性
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献13

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二级参考文献23

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共引文献27

中山大学学报（医学科学版）
2007年 第B06期

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