摘要
目的探讨不同疗法对表阿霉素外渗后局部组织损伤修复的理想方法,为临床护理提供依据。方法制作两种表阿霉素外渗动物模型(模型I为单纯表阿霉素外渗,模型Ⅱ为表阿霉素外渗伴局部组织淤血),分别采用临床常用的3种处理方法进行动物实验比较性研究,局部损伤组织后分别用50%葡萄糖水加维生素B12湿敷(A组),50%的硫酸镁湿敷(B组),2%利多卡因加地塞米松对局部损伤组织环形封闭(C组),未给予任何治疗者为对照组,同时对各组外渗性损伤的愈合时间、病理形态进行观察。结果3 d后观察各组损伤组织外观形态差异无显著性意义(P>0.05),第7天局部组织充血水肿、炎性细胞浸润显著消退,以50%葡萄糖水加维生素B12湿敷组为优,50%的硫酸镁湿敷对模型Ⅰ有较好疗效,2%利多卡因加地塞米松环形封闭对模型Ⅱ疗效较好;模型Ⅱ的病情、组织修复难度重于或大于模型Ⅰ。结论应根据表阿霉素外渗致局部组织损伤的不同特点选择合理的方法进行针对性处理。
Objective To find an ideal method for managing local tissue damage caused by extravasation of pharmorubucin. Method Two animal models were established, extravasation of pharmorubucin without other complications in Model Ⅰ,extravasation of pharmoruhucin complicates congestion in local tissue in Model Ⅱ. Three methods were introduced to manage local damages, hydropathic compress with vitamin B12 and 50% glucose（Therapy A）, hydropathic compress With 50% magnesium sulfate（Therapy B）, block damaged tissue in a ring shape with 2% lydocaine and hexadecadrol（Therapy C）,and a control group received no therapy. Recovery time of osmosis wound, pathological conformation in all group were observed and compared. Result No significant difference of tissue damage was found among 4 groups after 2days. Congestion,edema and inflammatory cell infiltration of local tissue were improved significantly after 7 days. Therapy A produces notable effects. Therapy B acquired good effects in managing congestion and edema of local tissue in Modal Ⅰ. Therapy C achieved satisfactory management in Model Ⅱ. The state of illness and repairing the tissue in Model Ⅱ are more difficult than Model Ⅰ. Conclusion Different methods managing tissue damage caused by extravasation of pharmorubucin should be chosen according to different characteristics of tissue damage.
出处
《护士进修杂志》
北大核心
2007年第21期1927-1929,共3页
Journal of Nurses Training
基金
四川省教育厅重庆科研基金资助项目(编号:2004A086
川教函[2004]329号)
关键词
血管外渗
表阿霉素
疾病模型
动物
Extravasation Pharmorubiein Model of disease Animal
