摘要
为观察豚鼠外淋巴瘘造模后畸变产物耳声发射（ＤＰＯＡＥ）的变化，选用１１只豚鼠右耳为实验耳，手术建立蜗窗外淋巴瘘。在实验前、打开听泡、蜗窗膜造瘘、缝合伤口及外淋巴瘘造后１８天，均以２ｆ１－ｆ２ＤＰＯＡＥ的幅值记录其变化。测试完毕后豚鼠耳蜗行火棉胶包埋切片，观察形态学改变。结果发现在形成蜗窗膜外淋巴瘘前后ＤＰＯＡＥ幅值变化差异有显著性（Ｐ＜０．０１），１８天后蜗窗膜愈合者ＤＰＯＡＥ幅值明显提高，接近实验前，而未愈合者则下降明显。病理检查见Ｃｏｒｔｉ器正常，愈合的蜗窗膜有上皮增生，肉芽及纤维母细胞。豚鼠形成外淋巴瘘后ＤＰＯＡＥ幅值明显下降，愈合后又上升，提示ＤＰＯＡＥ可作为外淋巴瘘辅助诊断的手段之一。
Perilymphatic fistula was induced in 11 healthy guinea pigs to study its effects on distortion product otoacoustic emissions (DPOAEs). DPOAE amplitudes decreased significantly right after formation of the fistula ( P <0 01), and recurred to near pretreatment level in animals whose fistula healed. The amplitude remained below pretreatment level 18 days after fistulizationn in those animals whose fistula failed to heal. Under light microscope, the organ of Corti was seen normal. The authors feel that DPOAEs may be helpful in dectecting perilymphatic fistula.
出处
《中华耳鼻咽喉科杂志》
CSCD
1997年第3期160-162,共3页
Chinese Journal of Otorhinolaryngology
