摘要
为了观察异体牙移植免疫原性，作者采用Ｃ５７ＢＬ／６和Ｂａｌｂ／ｃ两种主要组织相容性复合体（ＭＨＣ）完全不同的近交系小鼠作为实验动物模型，对异体牙的免疫原性进行研究。通过观察宿主抗体－补体介导的细胞杀伤ＡＣＭＣ、细胞介导的细胞杀伤ＣＭＣ，发现异体牙移植后，ＡＣＭＣ和ＣＭＣ与同基因型牙移植差异有显著性（Ｐ＜０．０５），说明异体牙有免疫原性，能引起宿主的排斥反应。
The mice used in this study were of the in bred strains C 57 BL/6 and Balb/c which differ at the major histocompatibility complex (MHC). The immunogenicity of tooth allografts was studied in vitro by means of detecting the response of Antibody Complement Mediated Cytotoxity (ACMC) and Cell Mediated Cytotoxity (CMC) of the host. We found that there was significant difference for both ACMC and CMC activity between the allogenic and isogenic tooth transplantation ( P <0.01). The results indicate that tooth allografts are immunogens and do evoke the immune response of recipients.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
1997年第3期158-160,共3页
Chinese Journal of Stomatology
关键词
牙移植
异体移植
免疫原性
Transplantation, homologous Immunogenicity
