摘要
中波紫外线是一种到达地球表面最具有生物活性的紫外线,是光生物学研究的主要对象。概述去氧核糖核酸、尿刊酸、活性氧系列、细胞因子及调节性T细胞方面的研究,尤其是重点讨论补体在中波紫外线导致免疫抑制方面的研究。在中波紫外线照射皮肤后,可使真皮内补体C3衍生为iC3b,,同时在一些因子作用下,血中单核细胞游移至真皮和表皮。它们表面的受体CR3和iC3b配体作用可上调白介素-10,而下调白介素-12,这一调节作用又与分裂原活化蛋白激酶,特别是对提高细胞外信号调节激酶相关。
Ultraviolet B （UVB） is the most biologically active ultraviolet reaching the earth＇s surface, and is a main research target for photobiology. This review focuses on the mechanisms of UVB induced immunosuppression. The scope of the investigation is as follows： 1）Deoxyfibonucleic acid, 2）Urocanic acid, 3） Reactive oxygen species, 4）Cytokines and 5） Regulatory T cells. Very recently, the research is further extended to complement. Alter UVB irradiation upon skin, complement C3 in dermis developed into iC3b. Meanwhile, with effects of other factors, monocytes from blood migrate into dermis and epidermis. The complement receptor CR3 on the surface of these cells then interact with ligand iC3b followed by upregualtion of IL-10 expression and downregulation of IL-12 expression. This regulation is related to mitogen-activated protein kinase, especially to the upregulation of extracellular signal-regulated kinase.
出处
《国际皮肤性病学杂志》
2007年第6期337-339,共3页
International Journal of Dermatology and Venereology
关键词
紫外线
免疫
补体系统蛋白质类
Ultraviolet rays
Immunity
Complement system proteins
