摘要
采用大鼠、小鼠脑缺氧模型观察了醒脑康制剂对其中枢缺氧的耐受性影响，并以电磁流量计测定了醒脑康提取液对犬脑循环的作用。结果表明，醒脑康可显著延长大、小鼠脑缺血性缺氧后的存活时间和夹闭大鼠气管后的脑电活动时间。ｉｖ给药，能明显扩张犬脑血管、降低脑血管阻力，增加脑血流量。在产生作用初期，可降低犬心肌张力—时间指数，并具有短暂的降压作用，但对动物心率无明显影响。
Effect of Xingnaokang formula(XNKF) on cerebral tolerance to anoxia was studied in rats and mice.The effects of XNKF on cerebral circulation were also examined by electromagnetic flow meter in dogs.The findings revealed that XNKF(6 0、12 0g/kg ig) significantly prolonged the survival time of the animals with cerebral ischimia anoxia and the lasting time of cerebral electrical activities in rats after their tracheae were blocked XNKF extraction (10 0、20 0g/kg iv) can also dilate the cerebral blood vessels,decrease the resistance of cerebral blood vessels,and increase the flow of cerebral blood in dogs.In the primary period of its action,XNKF extraction can lower the myocardial tension time index steadily and the blood pressure temporarily,but no effect on heartbeat in dogs.
出处
《中国实验方剂学杂志》
CAS
1997年第2期20-23,共4页
Chinese Journal of Experimental Traditional Medical Formulae
