摘要
目的:研究丝素活性肽对急性酒精中毒小鼠的防治作用。方法:解酒实验:80只小鼠随机分成4个组,各组均按7.56ml/(kgbw)的纯乙醇剂量灌胃56o白酒,0.5h后,生理盐水组灌胃生理盐水,样品组分别灌胃剂量为0.1、0.5、2.5g/(kg?bw)丝素肽溶液,测定小鼠醉倒率和醒酒时间。另有72只小鼠随机分为4个组,各组均灌胃6.16ml/(kg?bw)白酒,0.5h后,生理盐水组与样品组分别灌胃生理盐水与丝素肽溶液同上,在灌胃1、2、4h后测定小鼠血清中乙醇含量。防醉实验改成先给药,0.5h后再给酒。结果:灌胃0.5、2.5g/(kg?bw)丝素肽溶液两组的醒酒时间和乙醇含量均显著低于生理盐水组(P<0.05)。结论:丝素肽具有明显的解酒和防醉作用。
Objective： To study the preventive and therapeutic effects of silk fibroin peptides （SFP） on acute alcoholism in mice. Methods： In first experiment, the mice were randomly divided into four groups, and every group was treated by 56° alcohol （ethanol dosage 7.56 ml/kg bw） via i.g. Eighty mice were fed normal saline （NS） and different dosages of SFP （0.1, 0.5, 2.5 g/kg bw） 30 min later respectively, then the rate of ebriety and time of sobriety were determined. Another 72 mice were also divided into four groups and given NS and SFP similarly. The concentration of ethanol in serum was measured 1 h, 2 h and 4 h later respectively. In second experiment, the mice were also divided into four similar groups, but 56° alcohol was given at 6.16 ml/kg.bw via i.g. NS and SFP were given similarly, 0.5 h before alcohol. Two experiments were performed to observe the effect of SFP on prevention of temulence. Results： The time of sobriety and concentration of ethanol of SFP groups fed 0.5 and 2.5g/kg bw were lower significantly than those of NS group （P〈0.05）. Conclusion： Silk fibroin peptides had obvious preventive and therapeutic effects on acute alcoholism.
出处
《营养学报》
CAS
CSCD
北大核心
2007年第5期473-475,共3页
Acta Nutrimenta Sinica
关键词
丝素活性肽
酒精中毒
silk fibroin active peptides
alcoholism
