摘要
目的:探讨经皮冠状动脉介入治疗(PCI)前后β-血小板球蛋白(β-TG)浓度变化及其临床意义。方法:87例行PCI的患者分为不稳定型心绞痛组(40例)和稳定型心绞痛组(47例)。对照组35例为冠状动脉造影正常患者。ELISA法测定β-血小板球蛋白(β-TG)浓度。结果:β-血小板球蛋白(β-TG)浓度水平在PCI术后即刻较术前下降,随后逐渐升高,术后6h达到峰值。不稳定型心绞痛组β-血小板球蛋白(β-TG)浓度在术前及峰值水平均较稳定型心绞痛组升高。对照组患者β-血小板球蛋白(β-TG)浓度在冠状动脉造影前后无显著性变化。结论:血小板激活状态与斑块稳定性密切相关,血小板活性在PCI前后有动态改变,与PCI术后心肌损伤相关。
Objective： To study the state of PLT activation in patients with coronary heart disease （CHD） , who were treated with percutaneous coronary intervention （PCI）. The assessment of PLT activation was based on the concentration of β-TG as serum markers of the activation. Method：The study group consisted of 40 patients with unstable angina and 47 patients with stable angina pectoris, which were underwent PCI . An immunoenzymatic method （ ELISA, Stago Diagnostic） was used to measure the β-thromboglobulin blood plasma concentration. The control group consisted of 35 healthy subjects. Result： Post - procedural levels of β-TG showed a significant decrease compared with preprocedural levels, and then, tended to increase and arrived at the peak at 6 h after PCI. Preprocedural peak levels of β-TG were higher in patients with unstable angina than those in patients with stable angina pectoris. Conclusion： Concentrations of β-TG are increased in patients with CHD due to platelet activation. Intravascular platelet activation showed a dynamic change before and after PCI, and activation of platelet was positively related to stability of plaque and periprocedural myocardial damage.
出处
《河北医学》
CAS
2007年第10期1148-1151,共4页
Hebei Medicine
