摘要
目的探讨肝细胞癌（ＨＣＣ）患者癌组织与癌旁组织中雄、雌激素受体的变化．方法用葡聚糖包裹活性炭吸附法检测２１例ＨＣＣ患者的癌组织和癌旁组织中雄激素受体（ＡＲ）和雌激素受体（ＥＲ），同时测量７例男性肝硬变患者肝组织中的ＡＲ和ＥＲ．结果癌组织中ＡＲ阳性率（７１４％）显著高于癌旁组织（３１３％）（Ｐ＜００１）及硬变肝组织（Ｐ＜００５）中的ＡＲ阳性率（２８６％），而ＥＲ含量均无显著差异（Ｐ＞００５）．结论ＡＲ表达的增加与肝细胞的癌变有关，部分ＨＣＣ具有雄激素依赖性，为ＨＣＣ可能的内分泌治疗提供分子生物学方面的理论依据．
AIM To study the genuine role of sex hormone receptors in the development and growth of HCC in humans. METHODS Androgen receptors (AR) and estrogen receptors (ER) were consecutively assayed for hepatocellular carcinoma (HCC) and the surrounding noncancerous liver tissues. Specimens were obtained surgically from 21 men. AR and ER were detected in 7 other male patients with cirrhosis. The method of the dextran coated charcoal (DCC) was used. RESULTS Fifteen of 21 cases (71 4%) with HCC had AR (range 6 29fmol/mg～100fmol/mg cpr). ER existed in 6 (28 6%) tumors (range 3 0fmol/mg～61 43fmol/mg cpr). Among 7 cases of cirrhotic liver tissues, ER and AR were detected in 1 and 2, respectively. The AR titer was higher in the HCC than that either in the surrounding tissues ( P <0 01) or in 7 cirrhotic livers ( P <0 05). Serum alpha fetoprotein (AFP) level, HBV markers or histopathologic types of HCC had no correlations with the presence or absence of AR or ER and their titers. CONCLUSION The results suggested that the expression of androgen receptor should be augmented in association with malignant transformation of hepatocytes and some of the HCC are androgen dependent which respond to anti androgen agents.
关键词
肝癌
肝细胞癌
性激素受体
癌旁组织
Liver neoplasms\ \ Carcinoma, hepatocellular\ \ Receptors, androgen/analysis\ \ Receptors, estrogen/analysis
