摘要
患者女,42岁。因甲状腺功能亢进、结节性甲状腺肿,服用甲巯咪唑10mg,3次/d,利血生、普萘洛尔治疗1月。出现乏力、食欲不振、尿黄、皮肤重度黄疸,实验室检查显示:ALT1670U/L,AST1524.3U/L,TBil289.3μmol/L,DBil129.3μmol/L,ALB28.9g/L,A/G0.7,B超提示:肝回声偏粗。停用甲巯咪唑,其他药继续使用,并给予保肝治疗。1月后,患者症状逐渐好转,肝功能恢复正常。
A 42-year-old woman with hyperthyrosis and nodular goiter received thiamazole 10 mg thrice daily, leucogen, and prop- ranolol for one month. She developed asthenia, anorexia, dark urine, and severe yellowing of the skin. Laboratory tests revealed the following levels： ALT 1 670 U/L, AST 1 524.3 U/L, TBil 289.3μmol/L, DBil 129.3μmol/L, ALB 28.9 g/L, and A/G 0.7. A type-B ultrasonogrmn showed the echo of her liver was coarse, rllaimnazole was withdrawn and other drugs were continued. In addition, she received liver-protective treatment. One month later, the patient＇s symptoms improved gradually, and her liver function returned to normal levels.
出处
《药物不良反应杂志》
2007年第5期370-370,共1页
Adverse Drug Reactions Journal
关键词
甲巯咪唑
肝损害
thiamazole
liver impairment
