摘要
20世纪60年代初因发现沙利度胺有致畸作用将其撤出市场。但对沙利度胺的研究并未因此停止。60年代中期发现沙利度胺能有效治疗麻风结节红斑而再次引入临床。此后,沙利度胺用于治疗多种其他疾病。然而,在治疗过程中出现一些严重不良反应,如末梢神经病、血栓形成、血细胞减少以及肝毒性。了解这些不良反应无疑将有助于沙利度胺的安全应用。
Thalidomide was withdrawn from the market in the early 1960s after it was discovered that it produced teratogenic effects. Despite its withdrawal from market, thalidomide research did not discontinued. In the mid-1960s, it was found that thalidomide was an effective treatment for erythema nedosum leprosum; therefore, it was reintroduced to clinical practice. Since then, thalidomide has been used in several other diseases. However, serious adverse reactions, such as peripheral neuropathy, thrombosis, cytopenia, and hapatoxicity, occurred in thalidomide treatment. Understanding these adverse reactions no doubt is helpful to safe use of thalidomide.
出处
《药物不良反应杂志》
2007年第5期332-334,共3页
Adverse Drug Reactions Journal
