摘要
目的：观察川芎嗪联合参麦注射液治疗肺原性心脏病（肺心病）心力衰竭（心衰）的疗效方法。方法：应用川芎嗪联合参麦注射液治疗肺心病心衰４２例（治疗组），与应用常规西药强心利尿方法治疗的４０例（对照组）作对比。结果：治疗组显效率为５４．７６％，总有效率为９２．８６％；对照组显效率为３２．５０％，总有效率为７７．５０％。２组疗效比较有显著性差异（Ｐ＜０．０５）。治疗组治疗前后全血比粘度、血浆比粘度及红细胞电泳时间均有显著性差异（Ｐ均＜０．０５）。２组治疗后ＰａＯ２和ＰａＣＯ２均得到改善（Ｐ＜０．０５～０．０１），且治疗组明显优于对照组。治疗组治疗后１秒率（ＦＥＶ１％）和最大换气量（ＭＶＶ）均明显改善（Ｐ均＜０．０１）。结论：本疗法明显优于西药组，具有改善血液流变性、提高ＰａＯ２、ＦＥＶ１％、ＭＶＶ，降低ＰａＣＯ２等作用（Ｐ＜０．０５～０．０１），有救治率高、起效快、副作用小等特点。
Objective:To observe the therapeutic effects of tetramethylpyrazine combined “shen mai” injection in treatment of heart failure induced by cor pulmonale.Methods:Fortytwo cases were treated with tetramethylpyrazine combined with “shen mai” injection and compared to 40 cases with conventional western medicine(cardiac and diuretic drug).Results:The obvious effective rate was 54 76% and total effective rate was 92 86% in treatment group,while they were 32 50% and 77 50% respectively in control group.There was obvious difference between two groups( P <0 05).In the treatment group,there were significant differences in blood viscosity,plasma viscosity and the time of red blood cell electrophoresis before and after treatment (all P <0 05), and forced expiratory volume in one second (FEV 1%) and maximus voluntary ventilation (MVV) were improved after treatment (both P <0 01).Also,PaO 2 and PaCO 2 were improved significantly in the treatment group than in controls( P <0 05～0 01).Conclusions:The results show that therapeutic effect of tetramethylpyrazine combined “shen mai” injection is obvious superior to western medicine.In addition,it can improve hemorrheology,raise PaO 2,FEV 1% and MVV and decrease PaCO 2 ( P <0 05～0 01).It is presented some characteristic,such as high survival rate,initial cure quickly and lower sideeffect.
关键词
肺心病
心力衰竭
川芎嗪
参麦注射液
抗生素
cor pulmonale\ \ heart failure\ \ tetramethylpyrazine “shen mai” injection
