摘要
目的探讨2型糖尿病患者血清瘦素、皮质醇水平与胰岛素抵抗的关系。方法以稳态模型胰岛素抵抗指数(HOMA-IR)作为评估胰岛素抵抗程度的指标,采用放射免疫法测定瘦素与糖皮质激素水平,分别测定30例2型糖尿病患者和30例对照组患者的空腹血糖、空腹胰岛素、瘦素、皮质醇。结果2型糖尿病患者血清瘦素、糖皮质激素水平高于对照组,且呈正相关。多元逐步回归分析提示瘦素、糖皮质激素是胰岛素抵抗的独立影响因素。结论血清瘦素、皮质激素水平与胰岛素抵抗在2型糖尿病患者呈正相关,并且是2型糖尿病的独立危险因子。
Objective To study the relationship between serum leptin, glucocorticoids and insulin resistance in type 2 diabetes mellitus patients. Methods The homeostasis model assessment of insulin resistance （HOMA - IR） as a parameter was used to evaluate the degree of insulin resistance. The serum levels of leptin and glucocorticoids were measured by radioimmunoassay. The serum levels of FPG, insulin, leptin, glucocorticoids in 30 type2 diabetics and other 30 control group people were measured. Results The serum levels of leptin, glucocorticoids in type 2 diabetes mellitus were higher than those in control group（ P 〈 0.01 ）, and there was a significant correlation between them. Linear regression analysis showed that leptin and glucocorticoids were an independent factor influencing insulin resistance. Conclusions The serum levels of leptin and glucocorticoids in type 2 diabetes meUitus are significant related to insulin resistance. The serum levels of leptin and glucocorticoids are independent risk factors of type 2 diabetes mellitus.
出处
《浙江临床医学》
2007年第11期1447-1448,共2页
Zhejiang Clinical Medical Journal
基金
舟山市科技局科技计划项目(05573)
关键词
2型糖尿病
瘦素
糖皮质激素
胰岛素抵抗
diabetes mellitus type 2 leptin glucocorticoids insulin resistance
