摘要
目的观察小剂量阿司匹林对老年脑梗塞患者血小板胞浆游离钙浓度（〔Ｃａ２＋〕ｉ）的影响。方法采用钙荧光指示剂Ｆｕｒａ２ＡＭ，对２０例健康对照组和３０例老年脑梗塞患者血小板静息和激活状态下的〔Ｃａ２＋〕ｉ进行测定，并观察小剂量阿司匹林预防性给药对血小板〔Ｃａ２＋〕ｉ和脑梗塞病灶大小的影响。结果脑梗塞急性期血小板静息和激活状态下的〔Ｃａ２＋〕ｉ均明显高于健康对照组；小剂量阿司匹林的预防性给药对静息状态血小板〔Ｃａ２＋〕ｉ有明显的降低作用，静息状态下的血小板〔Ｃａ２＋〕ｉ与脑梗塞病灶的大小呈高度正相关。结论小剂量阿司匹林能降低老年脑梗塞患者血小板静息状态下的〔Ｃａ２＋〕ｉ，减小梗塞病灶的体积。
Objectivwe The influence of low dose aspirin on cytoplasmic free calcium concentrati on( Ca 2+ i)in blood platelets from aged patients with cerebral infarction was observed. Methods Ca 2+ iin baseline and activated state of blood platelets from 20 healthy controls and 30 aged patien tswith cerebral infarction were tested with Fura 2AM as a fluorescence indicator.The influence of pre ventive administration of low dose aspirin on Ca 2+ i in blood platelets and the size of cerebral infarc tswere observed. Results Ca 2+ iin baseline and activated state of blood platelets in patients at acute stage was obviously higher than that in the controls.Preventive administration of low dose aspirin obviously reduced Ca 2+ iin baseline state of blood platelets.A close correlation was present between Ca 2+ iin baseline state and the size of the infarcts. Conclusions Low dose aspirin can reduce Ca 2+ iin baseline state of blood platelet in aged patients with cerebral infarction and reduce the size of the infarcts.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
1997年第3期147-149,共3页
Chinese Journal of Geriatrics
基金
福建省卫生厅青年科学基金
