摘要
目的研究小剂量阿司匹林（ＡＳＡ，每天２５～５０ｍｇ）对老年人消化性溃疡并发出血危险性的影响。方法回顾性分析７０例老年消化性溃疡患者的临床资料，根据患者发现消化性溃疡时是否正在服用小剂量ＡＳＡ分为两组，对照分析两组并发上消化道出血的发生率及可能影响出血危险性的有关因素。结果两组患者的年龄、性别、既往溃疡病、溃疡病出血史及本次溃疡部位、大小和幽门螺杆菌感染率，差异均无显著性（Ｐ＞００５）。服ＡＳＡ组和未服ＡＳＡ组上消化道出血的发生率分别为５２９％和１７０％，差异有极显著性（Ｐ＜００１）。服小剂量ＡＳＡ患者并发上消化道出血的相对危险度为未服ＡＳＡ患者的５５倍，差异有极显著性（Ｐ＜００１）。结论服小剂量ＡＳＡ明显增加老年人消化性溃疡并发上消化道出血的危险性。
Objective To study the influence of low dose aspirin(ASA,25or50 mg daily)on the risk of bleeding from peptic ulcer in the elderly. Methods The clinical data of\ 70 elderl y patien tswith peptic ulcer were retrospectively investigated.They were divided into two groups according to ta k ing ASA or not.The incidence of uppergastrointestinal bleeding and factors affecting the risk of blee d ing from peptic ulcer were analyzed. Results The incidence of bleeding in ASA group(52 9%)was significantly higher than that in no ASA group(17 0%,P<0 01).The relative risk(RR)of pep tic ulcer with bleeding of ASA group was5 5(P<0 01).There wasno significant difference in age ,sex,pasthistory of ulcer and ulcer bleeding,ulcerlocation,ulcer size and the rate of helicobact erpyloris infection(P>0 05). Conclusion The use of low dose ASA(25 50mg daily)increas esthe risk of bleeding from peptic ulcer in the elderly.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
1997年第3期135-137,共3页
Chinese Journal of Geriatrics
