摘要
观察含4．6μmol／L巯甲丙脯酸（CPL）的停搏液及再灌注血液对低温体．外循环下犬心脏功能及血流动力学的影响。杂种犬24条，随机分为对照组（停搏液为St．Thomas停搏液改型）、CPL组（含CPL4．6μmol／L的St．Thomas停搏液改型及再灌注血液）及CPL十苯肾上腺素组（基本同CPL组，但在体外循环机内加苯肾上腺素2μg／kg，并在肾动脉开口以下阻断腹主动脉）。结果表明，心脏复跳后CPL组冠状动脉血流量、左心室收缩和舒张功能均明显优于对照组；增加外周血管阻力不影响冠状动脉血流量和心功能指标的恢复率。提示CPL可明显改善缺血再灌注后心功能，其机制可能与抑制心脏局部和体循环系统肾素-血管紧张素系统、抗自由基等作用有关。
The effects of cardioplegia and reperfusional blood containing 4. 6 μmol/L captopril (CPL) on the myocardial performances and hemodynamics of canine heart under hypothermic extracorporeal circulation were studied, Twenty four mongrel dogs were divided randomly into 3 groups。Control group: Only modified St. Thomas cardioplegia was used. CPL group: St. Thomas cardioplegia containing CPL 4. 6μmol/L was used and the same concen-tration of captopril in the circulatory blood was established before releasing the cross clamp. CPL+phenylephrine group: The concentration was the same as the CPL group, with an ad-ditional dose of phenylephrine (2 μg/kg) into the oxygenator and abdominal coarctation. The results revealed that the coronary blood flow and left ventricular contractility and relax-ation indices of CPL group were significantly improved than those of the control group, and increasing the systemic and pulmonary vascular resistence had no effect on the cardiac func-tion protected by captopril. It is suggested that captopril could ameliorate the recovery of myocardial performences by inhibitting myocardial and systemic renin-angiotensin system and scavenging free radicals.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1997年第3期212-216,共5页
Acta Academiae Medicinae Sinicae
基金
高等学校博士学科点专项科研基金
