摘要
目的:探讨血管紧张素转换酶抑制剂(ACEI)捷赐瑞对高血压患者尿微量蛋白(Alb)的影响。方法:将120例高血压患者分为捷赐瑞组、氨氯地平组各60例,在6个月的治疗期前后,测定血压、血肌酐、尿素氮、尿酸及尿Alb、α1-微量球蛋白、IgG。结果:两组治疗前后血压均有较明显的下降(P<0.05),但Alb的下降,捷赐瑞组明显优于氨氯地平组。结论:ACEI可明显降低高血压患者的血压,保护肾功能,其作用优于氨氯地平。
Objective To observe the effects of zestril on urine micmprotein in patients with essential hypertension （EH）, Methods One hundred and twenty patients with EH were derided into zestril group （n=60） and amlodipine group （n=60）. Blood pressure（BP）, serum creatinine （Scr）, blood urea nitrogen （BUN）, uric acid（UA）, urine microalbumin （mAlb）, α1-microglobulin （α1-MG）, i mmunoglobulins （IgG） were measured before and after 6 month treatment. Results BP of patients declined significantly after treatment in each group than that before treatment （P 〈 0.05）, and the mAlb declined significantly in zestril group than that in amlodipine group. Conclusion Zestril can more effectively decrease BP and protect the renal function of patients with EH than amlodipine.
出处
《实用医学杂志》
CAS
2007年第21期3413-3414,共2页
The Journal of Practical Medicine
关键词
高血压
蛋白尿
捷赐瑞
Hypertension Proteinuria Zestril
