摘要
目的观察奥美拉唑与法莫替丁联合治疗胃食管反流病(GERD)的疗效。方法92例GERD患者随机分为治疗组和对照组,前者清晨顿服奥美拉唑20mg,夜间睡前服法莫替丁40mg,后者仅清晨顿服奥美拉唑20mg,两者均予西沙比利5mg,3次/d,疗程8周。治疗前及疗程结束后行胃镜检查,观察其胃镜表现及反流症状的改善程度。结果治疗组46例中治愈34例,有效10例,无效2例,总有效率95.7%,对照组46例中治愈20例,有效12例,无效14例,总有效率69.6%。结论奥美拉唑与法莫替丁联合治疗GERD的疗效明显优于单用奥美拉唑者(P<0.05)。
[Objective] To study the efficacy of omeprazole combined with famotidine treating gastroesophageal reflux disease （GERD）. [Methods] 92 cases with GERD were randomly divided into control group and therapy group. The former was given of omeprazole 20mg in the morning and famotidine 40 mg nightly, the latter was only given of omeprazole 20mg in the morning. Two groups were treated with cisapride 5 mg tid. The course of treatment was 8 weeks. Endoscope examination was performed before treatment and after the course of treatment, and then the endoscopic appearance and reflux symptoms were observed. [Results] In the therapy group 34 cases were cured, 10 cases were partly effective, and 2 cases were ineffective, with the total efficiency was 95.7%. In the control group 20 cases were cured, 12 cases were partly effective and 14 cases were ineffective, with the total efficiency was 69.6%. [Conclusion] The efficacy omeprazole combined with famotidine treating GERD is obviously superior to the solo therapy of omeprazole（P 〈0.05）.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第20期2539-2540,2543,共3页
China Journal of Modern Medicine
关键词
奥美拉唑
法莫替丁
胃食管反流病
omeprazole
famotidine
gastroesophageal reflux disease
