摘要
肺动脉高压(PH),是以肺血管阻力进行性增高,肺血管重构和原位血栓形成为特征一大类疾病的总称。病理表现为肺毛细血管床数目减少,无肌细动脉肌化,阻力血管壁增厚,可伴有新生血管形成呈丛集样改变。其中肺小动脉中层平滑肌细胞增生,伴向内皮下迁移,分泌功能增强,造成血管壁增厚、管腔狭窄堵塞是PH特征性病理改变之一。近年来研究表明:5-羟色胺能促进肺动脉平滑肌细胞增殖肥大,在肺血管重构中起重要作用。它主要是在5-羟色胺受体(5-HT_(1B),5- HT_(2A),5-HT_(2B)受体)和5-羟色胺转运子(SERT)的参与下,通过不同的信号转导通路促使细胞增殖和肥大。血浆中较高的5 -羟色胺浓度,以及5-羟色胺转运子过度表达和基因多态性与PH的关系值得进一步去研究。
Pulmonary hypertension （PH） is characterized with an increase in pulmonary vascular resistance, pulmonary vascular remodeling and in situ thrombosis formation. Pathological changes include the reduction in the amount of pulmonary capillary bed, abnormal extension of muscular into peripheral non - muscular arterioles, intimal hyperplasia with plexiform lesion. Medial smooth muscle cell proliferation and migration into intimal layer leading to narrowing and occlusion of vascular lumen is one of characteristics of pulmonary hypertension. Accumulating evidence show that serotonin, a moderate mitogen, plays an important role in proliferation of pulmonary arterial SMCs and vascular remodeling during progression of pulmonary hypertension. Recent researches manifest that serotonin receptors as well as serotonin transport （SERF） participates in serotonin -induced pulmonary arterial SMCs hyperplasia and hypertrophy via different signal transduction pathways. The associations linking elevated serum serotonin concentration, serotonin transporter overexpression and serotonin transporter gene polymorphism with susceptibility to clinical PH patterns are uncertain till now and deserve to further study.
出处
《国际麻醉学与复苏杂志》
CAS
2007年第5期441-444,共4页
International Journal of Anesthesiology and Resuscitation
关键词
肺动脉高压
肺动脉平滑肌细胞
5-羟色胺
pulmonary hypertension
pulmonary arterial smooth muscle ceils
serotonin
