期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

三种降脂中成药对Apo-AI及SR-BI相互作用影响的研究 被引量：3

暂未订购
导出
摘要 目的:利用酵母双杂交系统观察三种临床常用的降脂药对大鼠apo-AI和SR-BI蛋白间相互作用的影响;方法:通过报告基因β-半乳糖苷酶的活力,比较三种临床常用的降脂中成药对大鼠apo-AI和SR-BI蛋白间相互作用能力的影响;结果:通过比较报告基因β-半乳糖苷酶活力的活力,观察到与空白对照相比,黄芪注射液、银杏叶片、复方丹参滴丸在一定浓度都可提高β-半乳糖苷酶活力。结论:黄芪注射液、银杏叶片和丹参滴丸在一定浓度显著增强apo-AI及清道夫受体SR-BI间的相互作用,促进胆固醇逆转运,其降脂作用可能部分是通过此途径完成的。
作者 信学雷 李维琪 张云峰 阿吉艾克拜尔.艾萨 汪汉卿
机构地区 中国科学院兰州化学物理研究所 中国科学院新疆理化技术研究所
出处 《中药药理与临床》 CAS CSCD 北大核心 2007年第5期129-131,共3页 Pharmacology and Clinics of Chinese Materia Medica
基金 中国科学院"西部之光"计划资助项目
关键词 黄芪注射液 银杏叶片 复方丹参滴丸 Apo-AI SR-BI Β-半乳糖苷酶
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献8

  • 1刘晓辉.抗动脉粥样硬化的新靶位─高密度脂蛋白受体SR-BI[J].国外医药（抗生素分册）,2003,24(2):70-73. 被引量：6
  • 2Ryan E Temel, Rosemary L, Walzem CL, et, al. Apolipoprotein A - I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI - mediated cholesterol ester - selective uptake. J Biol Chem, 2002 ; 277 (29) : 26565 - 26572
  • 3Tong Liu ,Monty Krieger, Horng - Yuan Kan, et,al. The effects of mutations in Helices 4 and 6 of Apo - AI on scavenger receptor class B type I ( SR - BI ) - mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR - BI Is required for efficient lipid transport . J Biol Chem. , 2002 ;277 (24) : 21576 -21584
  • 4信学雷,陈志慧,李维琪,刘云英,麦迪娜,张云峰.用酵母双杂交系统研究载脂蛋白AI(apoAI)和清道夫受体BI(SR-BI)间的相互作用[J].中国生物工程杂志,2005,25(5):80-84. 被引量：4
  • 5Estojak J, Brent R, Golemis E A. Correlation of two - hybrid affinity data with in vitro measurement. Mol Cell Biol,1995 ; 15:5820 - 5829
  • 6Miller J H. In a short course in bacterial genetics. Cold spring harbor laboratory press, cold spring harbor,1992:74
  • 7Young K, Lin S, Sun L, et al. Identification of calcium channel modulator using a high throughput yeast two - hybrid screen. Nature Biotechnology, 1998 ;16:946 -950
  • 8Liu Jew, Jeannine E and Packard Dental. The anti - estrogen hydroxytanmoxifen is a potent antagonist in novel yeast two - hybrid system. Biochem, 1999;380:1341 - 1345

二级参考文献18

  • 1Silver D L Tall A R.The cellular biology of scavenger receptor class B type Ⅰ[J].Curr Opin Lipidol,2001,12:497-497.
  • 2萨姆布鲁克J 拉塞尔DW 黄培堂 王嘉玺 朱厚础 译.分子克隆实验指南(第3版)[M].北京:科学出版社,2002.2-140.
  • 3Koji M, Yoshinaru W, Takaaki N. Effects of glucose and insuslin on rat apoliporoteinA-I gene expression. J Bio Chem, 1998, 273(30) : 18959 - 18965.
  • 4Ponsin G T, Pulcini J T, Sparrow A M, et al. High density lipoprotein interconversions in rat and man as assessed with a novel nontransferable apolipopeptide. J Biol Chem, 1993, 268 : 3114 -3119.
  • 5Gao G, Garcia C K, Wyne K L, et al. Structure and localization of the human gene encoding SR-BI/CLA-1 : evidence for transcriptional control by steroidogenic factor 1. J Biol Chem,1997, 272 : 33068 - 33076.
  • 6Trigatti K B, Rayburn H, Vinals M, et al. Influence of the highdensity lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology. Proc Nail Acad Sci USA, 1999,96 : 9322 - 9327.
  • 7Temel R E, Walzem R L, Banka C L, et al. Apolipoprotein A-I is necessary for the in Vivo formation of high-density lipoprotein competent for scavenger receptor BI-mediated cholesteryl esterselective uptake. J Biol Chem, 2002,277(29): 26565 - 26572.
  • 8Liu T, Krieger M, Kan H Y, et al. The effects of mutations in helices 4 and 6 of APOA-I on scavenger receptor class B type I(SR-BI)-mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for efficient lipid transport. J Biol Chem,2002, 277 (24): 21576 - 21584.
  • 9Greene D J, Skeggs J W, Morton R E. Elevated triglyceridec content diminishes the capacity of high density lipoprotein to deliver cholesteryl esters via the scavenger receptor class B type I (SRBI). J Biol Chem, 2001, 276(7): 4804-4811.
  • 10Vials M, Xu S, Vasile E, et al. Identification of the N-linked glycosylation sites on the high density lipoprotein (HDL) receptor SR-BI and assessment of their effects on HDL binding and selective lipid uptake. J Biol Chem, 2003,278(7) : 5325 - 5332.

共引文献8

同被引文献36

引证文献3

二级引证文献12

中药药理与临床
2007年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部