摘要
目的:探讨黄芪配伍当归(QG)对气虚血瘀模型大鼠心肺血管内皮和肝窦内皮细胞CD54表达的影响。方法:用饥饿+游泳制造"气虚血瘀"大鼠模型,灌胃给药15d后测定心肺血管内皮和肝窦内皮细胞CD54的表达。结果:气虚血瘀模型大鼠心肺血管内皮和肝窦内皮细胞CD54的表达明显增高,QG能显著降低其过度表达。结论:QG益气活血作用与降低心肺血管内皮和肝窦内皮细胞CD54的过度表达有关。
Objective： To investigate the influence of Astragalus membranaceus combined with Angelica sinensis （QG for short） on the expression of CD54 in vessels endothelial cells（VECs） and hepatic sinusoid endothelial cells（HSECs） of Qi - Deficiency and Blood - Stasis model rats. Methods： Using the method of hunger and fatigue to establish Qi - Deficiency and Blood - Stasis model rats, measuring the expression of CD54 in VECs and HSECs after ig administrate for 15d. Results： The expression of CD54 in VECs and HSECs of Qi - Deficiency and Blood - Stasis model rats markably raised, QG can effectively decrease their excessive expression. Conclusion ： Inhibiting the excessive expression of CD54 in VECs and HSECs may be one of the molecular mechanism of Replenishing Qi and Promoting Blood Circulation of QG.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2007年第5期39-41,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
芪归药对
血管内皮细胞
肝窦内皮细胞
CD54
Astragalus and Angelica herb couple
endothelial vessels cells
hepatic sinusoid endothelial cells
CD54
