摘要
目的探讨血清癌胚抗原125(CA125)和乳酸脱氢酶(LDH)在非霍奇金淋巴瘤(NHL)中诊断和治疗中的临床意义。方法对40例NHL患者分别应用放射免疫法和酶联法测定CA125和LDH水平,分析在不同的临床分期和治疗结果中意义。结果①NHL患者的血清CA125为47.82+78.40U/ml、LDH为282.85+237.24U/L,分别高于正常对照组的8.12+4.43U/L和146.65+35.09U/L,与对照组比较均有显著性差异。②完全缓解(CR)和部分缓解(PR)25例NHL患者的CA125和LDH水平分别低于15例复发(PD)的患者。19例Ⅰ期和Ⅱ期患者的CA125水平低于21例Ⅲ期和Ⅳ期患者,但LDH水平则在分期之间无明显统计学差异。③LDH升高而CA125升高的患者明显高于LDH正常而CA125升高的患者。结论血清CA125和LDH在NHL的诊断、临床分期、疗效判定和预后等方面有较为重要的意义。
Objective To study the clinical significance of serum CA125 and LDH determination in diagnosis and prognosis of patients with non - Hodgkin lymphoma（NHL）. Methods The serum levels of CA125 and LDH in 40 cases with NHL were measured by radioimmunoassay and enzyme - linked immunoassay respectively. Results （1）The serum levels of CA125 and LDH in 40 cases with NHL were 47.82 ＋ 78.40 U/ml and 282.85 ＋ 237.24 U/L respectively, which were higher than those in control group （ P 〈 0.05 ）. （2）The serum levels of CA125 and LDH in CR （complete response） and PR（ partial response） patients were lower than those of PD（ progressive disease） patients. （3）The serum levels of CA125 in phase Ⅰ and phase Ⅱ patients were lower than those in phase Ⅲ and phase Ⅳ patients. Conclusion The serum levels of CA125 and LDH can be taken as auxiliary clinical indexes for diagnosis, evaluation of the effectiveness of treatment and prognosis in patients with NHL, and they have important clinical significance.
出处
《临床和实验医学杂志》
2007年第11期35-36,共2页
Journal of Clinical and Experimental Medicine
