摘要
目的院前尿激酶(UK)静脉溶栓治疗急性心肌梗死临床观察。方法统计心电图ST段抬高的从症状发作到溶栓开始的时间均<6h的心肌梗死(AMI)病人60例,院前组住院前溶栓27例,院后组33例,用尿激酶静脉溶栓治疗,两组进行比较分析。结果住院前溶栓病人从症状发作到溶栓开始的平均时间为3.1(3.8±2.2)h,院后溶栓者为4.5(4.0±2.0)h;住院前溶栓病人再通率为81.5%,院后溶栓者为73.9%;病死率分别为3.7%和9.1%,1年生存率分别为93%和88%。在症状发作2h内住院前溶栓病人中,住院35d病死率为0%,1年生存率为99%,较早的PHT治疗病人1年生存率较高。结论院前尿激酶溶栓治疗,溶栓时间提前,增加溶栓后血管再通率,降低病死率,提高存活率,改善远期预后。
Objective To observe the clinical efficacy of intravenous thrombolytic therapy using urokinase in acute myocardial infarction in prehospital care. Methods Sixty cases （ symptom duration before thrombolytic therapy 〈 6 h） with ST - segment elevation acute myocardial infarction （STEMI） ,were divided into two groups： pre-hospital therapy （27 cases） and inhospital therapy （33 cases）. Both groups were treated by intravenous urokinase and the results were compared. Results The average time from onset of chest pain to thrombolytic therapy was 3.1 （ 3.8 ± 2.2） hours （ prehospital care） and 4.5 （4.0 ±2.0） hours （ inhospital therapy ）. The recanal;zation rate of thrombolytic therapy was 81.5 % in prehospital group versus 73.9% in inhospital group（ P 〈0.05）. Mortality was 9.1% in inhospital group versus 3.7% in prehospital group （ P 〈0. 05 ）. One - year survival rate was 93% in prehospital group versus 88% in inhospital group and 35 - day mortality was 0. One - year survival rate was higher when the starting time of thrombolytic therapy was earlier after the onset of chest pain. Conclusion Thrombolytic treatment in acute myocardial infarction in prehospital care is associated with higher recanalization rate, lower mortality,and improved long term pregnosis.
出处
《临床和实验医学杂志》
2007年第11期9-10,13,共3页
Journal of Clinical and Experimental Medicine
