摘要
为了研究温郁金（Curcuma wenyujin Y.H.Chen et C.Ling）根茎中的倍半萜类成分,采用大孔树脂和反复硅胶柱色谱对温郁金干燥根茎的50%乙醇提取物进行分离纯化,得到8个倍半萜类化合物1～8;其化学结构通过多种波谱方法分别鉴定为温郁金内酯A（wenyujinlactone A,1）、neolitamone A（2）、zedoarondiol（3）、isozedoarondiol（4）、aerugidiol（5）、莪术醇（curcumol,6）、莪二酮（curdione,7）和（1R,10R）-epoxy-（-）-1,10-dihydrocurdine（8）.化合物1为新的桉叶烷型倍半萜内酯,化合物2～5为首次从该植物中分离得到.
The aim of the study was to investigate the sesquiterpene constituents from the rhizomes of Curcuma wenyujin Y．H．Chen et C．Ling．The isolation and purification of the constituents from the 50％ EtOH extracts of the rhizomes were performed with repeated column chromatography over sillica gel and macroporous resin．Eight sesquiterpenes were obtained and identified as wenyujinlactone A（1）,neolitamone A（2）,zedoarondiol（3）,isozedoarondiol（4）,aerugidiol（5）,curcumol （6）,curdione （7） and （1R,10R）-epoxy-（-）-1,10-dihydrocurdine （8） by means of spectral analysis．Among them,compound 1 was found to be a new eudesmane sesquiterpene lactone,whilst compounds 2-5 were obtained from this plant for the first time．
出处
《药学学报》
CAS
CSCD
北大核心
2007年第10期1062-1065,共4页
Acta Pharmaceutica Sinica
基金
Project supported by National Natural Science Foundation of China(20372014).
关键词
温郁金
倍半萜
温郁金内酯A
Curcuma wenyujin
sesquiterpene
wenjujinlactone A
