摘要
合成了纳米尺寸的羟基磷灰石粒子并对其进行表征,研究了牛血清白蛋白作为模式蛋白对羟基磷灰石纳米粒子的吸附量,探索了影响其吸附的因素(如pH,Ca2+,PO33-),同时测定了羟基磷灰石纳米粒子-牛血清白蛋白复合物的体外释放度。实验结果表明:羟基磷灰石纳米粒子能够作为蛋白类缓释药物的载体。
Nano-sized hydroxyapatite （nsHAp） was synthesized to examine its possibility as a controlled release carrier of protein. In order to achieve effective protein release from nano-sized hydroxyapatite it was necessary to study the adsorptive property of protein on nsHAp and the influence parameters, such as pH, calcium and phosphate, on the adsorption process. Nano-sized hydroxyapatite particles were synthesized and characterized. Bovine serum albumin （BSA） was selected as the model protein. Meanwhile, the release kinetics of BSA adsorbed onto the nsHAp （nsHAp-BSA） was examined. The experiment results show that nano-sized hydroxyapatite particles can be successfully used as controlled release carrier of protein.
出处
《吉林大学学报（工学版）》
EI
CAS
CSCD
北大核心
2007年第5期1093-1096,共4页
Journal of Jilin University:Engineering and Technology Edition
基金
'863'国家高技术研究发展计划项目(3F0035951413)
吉林大学研究生创新基金资助项目(304003)
关键词
纳米材料
羟基磷灰石
牛血清白蛋白
缓释药物
nanomaterials
hydroxyapatite
bovine serum albumin
controlled release
