摘要
目的:了解2型糖尿病患者的外周血管病变(PVD)与炎症因子之间关系。方法:选择2型糖尿病患者。踝肱比(ABI)值<0.9为外周血管病变组(PVD组),≥0.9者为非外周血管病变组(N-PVD组)。比较两组的人超敏C反应蛋白(hsCRP)、肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)3项炎症因子指标,以及体重指数(BMI)、血压、血糖、糖基化血红蛋白、血脂水平、病史等方面的差异。结果:PVD组hsCRP水平高于N-PVD组(0.61±0.72vs0.12±0.93,P<0.001)。当hsCRP水平大于0.83时患PVD的危险有明显增加(OR值为11.08)。在PVD组中,有心脑血管病患者的IL-6水平高于无心脑血管病者(0.48±0.43vs1.02±0.40,P<0.001)。PVD组患者年龄、纤维蛋白原水平以及中风患病率均高于N-PVD组;PVD组的舒张压小于N-PVD组。结论:炎症因子在2型糖尿病患者的PVD发生发展中具有临床价值。在2型糖尿病患者中,PVD患者的hsCRP水平高于非PVD患者。当hsCRP水平高于0.83mg/L时,OR值可达到11.08,值得临床高度重视。作为CRP的调节因子,IL-6能否作为早期动脉硬化的指标还有待于进一步的研究。
Objective：To investigate the relationship between inflammation factors and peripheral vascular disease（PVD） in Type 2 diabetes（T2DM） patients. Method：The level of inflammation factors including hsCRP,IL-6,TNF-α were compared between PVD patients（ABI 〈 0.9） and N-PVD patients（ABI≥0.9）, and the differences in body mass index （BMI）,blood pressure （BP）,serum glucose,HbA1c,and history were also observed. Result：The hsCRP level in PVD was significantly higher than that of N-PVD（0.61 ± 0.72 vs 0.12 ± 0.93,P 〈 0.001）. The risk of PVD obviously increased when hsCRP was higher than 0.83 mg/L. The patients with cardiocerebrovascular disease had higher level in IL-6 than those who didn＇t have such disease in PVD group. The PVD patients were older,while with higher level of fibrinogen ,more prevalent of stroke and lower diastolic blood pressure than that of the N-PVD ones. Conclusion：Inflammation factors had the similar clinical importance for the onset and progress of PVD pateints with cardiocerebrovascular disease. The existence of PVD should be paid affention to when the level of hsCRP was higher than 0.83 mg/L.Perhapse IL-6 was an alarm for initial atherosclerosis. Aging was one of the major risk factors of PVD in T2DM patients. There were unclear relationships between PVD and things such as fibrinogen,hypertension,and cerebrovascular disease.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2007年第9期1005-1008,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省卫生厅医学发展重大课题(H200213)
关键词
2型糖尿病
外周血管病变
炎症因子佑
type 2 diabetes
peripheral vascular disease
inflammation factors
