摘要
目的:了解《中华精神科杂志》10年间有关药物疗效文章的资料情况。方法:采用回顾性研究分析,分析《中华精神科杂志》10年间有关药物疗效文章的资料。结果:10年间《中华精神科杂志》刊登有关药物疗效研究文章有126篇,占11.3%;10年间,精神科药物疗效研究的特点及暴露出的问题表现在:①大样本含量研究(占20.6%)相对不足;②疾病对象仍集中在精神分裂症(占50.0%)、情感障碍(占26.2%)两大疾病中;③双盲随机对照的文章数(占23.1%)偏低,部分人员忽视对照组资料的全面性与均衡性;④部分作者忽视诊断标准(占17.4%),疗效标准(占14.3%)的描述,部分作者注意统计意义而忽视临床意义。结论:精神科药物疗效研究应遵循GCP原则,加强大标本、设计合理的高水平研究;继续强化诊断标准与疗效标准的使用,使之朝国际化发展。
Objective： To review the papers of psychiatrical clinic trials published on Chinese Journal of Psychiatry in recent ten years. Methods： All articles published from year 1996 to 2005 on this journal were retrospectively evaluated by statistical and epidemiologic method. Results： A total of 126 papers on psychiatrical drugs＇ outcomes （11.3% of all articles） were published. The trials with large sample size were only 20.6%. Most subjects involved were schizophrenia （50. 0%） and emotional handicap （26. 2%） patients. Double-mask radomized control trials were only 23.1%. Some of papaers were lack of standard descriptions for dianosis （17. 7%） or curative effects. Conclusion： Psychiatrical clinic trials should be designed according to the GCP protocols with large sample size. The criterions for diagnosis and curative effect should be listed in the articles.
出处
《武汉大学学报（医学版）》
CAS
2007年第6期826-828,共3页
Medical Journal of Wuhan University
关键词
精神病药物
医学期刊
回顾性研究
Psychiatric Drugs
Medical Journals
Retrospective Study
