摘要
对２３例小儿肝母细胞瘤的临床病理学进行了研究，并分析了病理学改变与预后的关系。本组肿瘤均为手术切除标本，用组织化学ＨＥ染色和免疫组化ＡＦＰ检测。结果表明，该肿瘤病理形态特点为瘤体大，最大直径４５ｃｍ；主要成分为胚胎性肝上皮组织，部分病例有胚胎性或较成熟的间叶组织。肿瘤发生在肝左叶或边缘部者预后较好，瘤体大或多结节型者预后差；胎儿型和混合型预后好，未分化型预后差；肝脏血液循环丰富，肝母细胞瘤生长速度快，易侵袭破坏血管发生血行转移，这是影响其预后的重要因素。
To analyse the relationship between the pathological changes and the prognosis of hepatoblastoma through the pathological study on 23 cases of hepatoblastoma in infancy and childhood. Twenty-three hepatoblastomas were surgical specimens. The study was performed by using the common and immunohistochemical stainings. The morphologic features were , 1. the tumors are larger in size , the maximum being 45 cm in diameter; 2. the main elements were embryonic epithelial tissues of the liver , and immature mesenchymal tissues in some of the tumors. The clinicopathological observations show that the main factors affecting the prognosis include location , size , type and biological behavior of the tumor. The prognosis of tumors in the left lobe or on the edge of the liver is favorable , and that of large tumors and tumors with multiple nodules is unfavorable. The prognosis of fetal and mixed type one. is good , and that of undifferentiated type tumors is poor. The biological behavior. of hepatoblastomas shows the rapid growth of the tumors as a result of the massive blood circulation in the liver and the consequent vascular invasion presented metastatic growths that is the most important factor effecting the prognosis
出处
《山东医科大学学报》
1997年第2期98-101,共4页
Acta Academiae Medicinae Shandong
