摘要
目的观察转化生长因子β(TGF-β)、可溶性细胞黏附分子-1(sICAM-1)在慢性乙型肝炎患者中的水平变化,以及肝损害的不同程度与TGF-β、sICAM-1的关系。探讨TGF-β、sICAM-1对于肝病诊断的临床意义。方法对75例慢性乙型肝炎患者,采用ELISA法检测血清TGF-β、sICAM-1水平。结果75例慢性乙型肝炎患者血清TGF-β、sICAM-1水平均有不同程度的升高。慢性肝炎中度和重度者较正常对照组升高明显,差异显著(P<0.01)。慢性肝炎轻度与正常对照组相比无显著差异(P>0.05)。结论血清TGF-β、sICAM-1的水平变化,可作为反映肝组织炎症损害程度的较为灵敏的指标,对于判断慢性乙型肝炎病情变化,有一定的临床价值。
Objective To investigate the clinical significance of serum levels of TGF-β and sICAM-1 in patients with chronic viral hepatitis B. Methods ELISA was used to measure the serum levels of TGF-β and sICAM-1 in 75 patients with chronic viral hepatitis B. Results The serum levels of TGF-β and sICAM-1 in patients with moderate and serious chronic viral hepatitis B were significantly higher than those in normal control group（ P 〈0.01 ）. Conclusion Combined detection on the levels of serum TGF-β and sICAM-1 will reflect the damage degree of liver tissue in patients with chronic viral hepatitis B and be helpful to the prediction of prognosis and instruction of chronic viral hepatitis B treatment.
出处
《临床消化病杂志》
2007年第5期311-312,共2页
Chinese Journal of Clinical Gastroenterology
