摘要
目的研究喘息患儿血清特异性IgE(sIgE)的变化,了解喘息患儿过敏原分布情况,为其防治提供科学依据。方法采用体外特异性过敏原检测试剂盒对324例喘息患儿进行吸入过敏原(IVT701)和食物过敏原(IVT702)检测。结果①婴幼儿(≤3岁)和年长儿(>3岁)总IgE阳性率分别为61.29%和95.08%(χ2=44.97,P<0.01);②支气管哮喘患儿血清总过敏原和单一过敏原均高于喘息性支气管炎患儿;③吸入过敏原中尘螨、霉菌、豚草花粉年长儿阳性率明显高于婴幼儿;食物过敏原中鱼虾蛋白阳性率最高,蛋黄蛋白阳性率婴幼儿明显高于年长儿。婴幼儿以食物过敏原为主,年长儿以吸入过敏原为主。结论本地区尘螨、霉菌、豚草花粉、鱼虾蛋白为常见过敏原。随着年龄增长,食入性过敏反应逐渐减少,吸入性过敏反应相对增加。过敏原分布随年龄、地区、气候不同而有差异。明确过敏原对特异性免疫治疗具有指导意义。
Objective To detect serum specific IgE level in wheezy children , analysis the allergen spectrum characteristics, and provide scientific basis for prevention and treatment. Methods 324 children with wheezing were recruited for the reactions to IVT701 and IVT702 test with serum-specific IgE. Results （1）The total IgE-posltive of infant （ ≤3 岁 ） and toddler（ 〉 3 岁 ） were 61.29% 和 95.08% （x^2 =44. 97 ,P 〈0.01 ） ;（2）Total serum allergen and single serum allergen in asthma were higher than those in asthmatoid bronchitis ;（3）The positive rates of dust mites, fungi and ragweed in wheezy toddler were higher than wheezy infant;The positive rate of fish and shrimp was the highest in food allergen, the positive rate of egg white and egg yolk in infant was higher than toddler. Food allergy predominated in wheezy infant and inhalation allergy in wheezy toddler. Conclusion Dust mite, fungi, ragweed , fish and shrimp were the common allergens in our area. With the increase of age, food allergy reactions decreased,inhalation allergy reactions increased. Allergen spectrum characteristics was different with area, age and climate. The results may provide the guildline immunotherapy,in particular desensitization treatments.
出处
《中国医刊》
CAS
2007年第11期47-48,共2页
Chinese Journal of Medicine
