摘要
通过单独和联合在腹腔内注射ＣｄＣｌ２（３ｍｇ／ｋｇ体重）和Ｎａ２ＳｅＯ４（２ｍｇ／ｋｇ体重）的方法研究硒对镉诱导的小鼠肝脂质过氧（ＬＰＯ）的保护效应。结果表明，单独镉处理小鼠在整个实验期间肝丙二醛（ＭＤＡ）含量明显升高，谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）、超氧化物歧化酶（ＳＯＤ）和过氧化氢酶（ＣＡＴ）活性显著下降；硒镉联合处理未引起ＬＰＯ的明显增强，抗氧化酶特别是ＧＳＨ－Ｐｘ在不同程度上受到有效地保护。因而认为，镉诱导的ＬＰＯ与抗氧化酶的抑制密切相关。
The protective effect of selenium on cadmium—induced lipid peroxidation(LPO) in mouse livers was evaluated by intraperitoneal injection of CdCl 2(3mg/kg body weight)and Na 2SeO 4(2mg/kg body weight)alone as well as in combination.Cadmium treatment alone led to a marked increase of malondialdehyde(MDA) level and significant inhibition of gluthione peroxidase(GSH Px),superoxide dismutase(SOD) and catalase(CAT),as compared with cadmium and selenium coexposure as well as control.The cadmium and selenium coexposure didnt produce a more pronunced elevation in LPO than control.Meanwhile,the activity of antioxidant enzymes,especially GSH Px was effectively protected to a certain extent.It follows that cadmium induced LPO was closely associated with the inhibition of antioxidant enzymes and protective role of selenium was realized mainly by enhancing GSH Px activity.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
1997年第4期304-310,共7页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
甘肃省自然科学基金
关键词
硒
镉
小鼠
脂质过氧化
抗氧化酶
Cadmium,Selenium,Mice,Lipid peroxidation,Antioxidant enzymes
