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血清谷氨酸脱羧酶抗体与孤立病灶的脱髓鞘及多发性硬化的相关性研究 被引量:1

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摘要 目的了解孤立病灶的脱髓鞘及多发性硬化(MS)患者血清中谷氨酸脱羧酶抗体(GAD-Ab)水平,探讨它们之间的相关性以及GAD-Ab在中枢神经系统炎性脱髓鞘性疾病发病中的作用。方法选择临床确诊的MS患者45例(CDMS组)和临床孤立综合征(CIS)患者63例(CIS组),测定血清中GADAb滴度及阳性率并与体检健康者30例(HC组)进行比较。结果CDMS组血清GAD-Ab阳性率为40.0%,CIS组血清GAD-Ab阳性率为27.0%,而HC组无一例阳性。结论通过测定CIS患者的血清GAD-Ab,有助于早期发现表现为CIS的MS患者。
出处 《中国医师进修杂志(内科版)》 2007年第11期51-52,共2页 Chinese Journal of Postgraduates of Medicine
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