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尿激酶型纤溶酶原激活物及其抑制物与肝纤维化 被引量：1

Urokinase-type plasminogen activator with its inhibitor and liver fibrosis
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摘要 肝纤维化是肝脏对慢性损伤的一种修复反应,以细胞外基质(ECM)在肝内过多沉积为特征。尿激酶型纤溶酶原激活物(uPA)及其抑制物(PAI)是调节基质金属蛋白酶(MMP)活性和ECM降解的关键因素。uPA通过uPA-纤溶酶-MMP级联反应途径,最终可产生活化的纤溶酶和MMP,后两者是降解ECM的重要物质。因而调控uPA的表达,可能为肝纤维化的治疗提供新的途径。 Liver fibrosis is a hepatic wound-healing response to chronic injury, and is characterized by excessive ECM deposition in liver, uPA and its inhibitor play an important role in MMP activity regulation and ECM degradation, uPA activates MMP and plasmin through uPA-plasmin-MMP cascade reaction, which are the important substances in degradation of ECM. So regulation of uPA expression may provide a novel tool for the treatment of liver fibrosis.
作者 孙超 李定国
机构地区 上海交通大学医学院附属新华医院消化内科
出处 《国际消化病杂志》 CAS 2007年第5期364-366,共3页 International Journal of Digestive Diseases
关键词 尿激酶型纤溶酶原激活物 纤溶酶原激活物抑制物 肝纤维化 Urokinase-type plasminogen activator Plasminogen activator inhibitor Liver fibrosis
分类号 R575.2 [医药卫生—消化系统]
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参考文献19

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共引文献2

同被引文献13

  • 1王俊然,郑素勤.肾小管上皮细胞转分化的调控机制及药物干预作用[J].华北煤炭医学院学报,2007,9(2):179-181. 被引量：1
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  • 10李筠,李宝明,李利阳.82例原发性高血压患者尿微量白蛋白与脉压关系的观察[J].医学综述,2009,15(2):304-305. 被引量：2

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国际消化病杂志
2007年 第5期

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