摘要
肝卵圆细胞是一类存在于成年肝脏、具有自我更新和多向分化潜能的肝干细胞。当肝脏发生严重损伤且肝细胞再生障碍时,卵圆细胞被激活并大量增殖,参与肝脏损伤的修复与重建。肝卵圆细胞增殖分化是多因素作用的结果。现就肝卵圆细胞的定位、来源及调控机制的研究进展作一概述。
Hepatic oval cells（HOC） are the progenitor cells existing in the adult liver, with the capacity to self-renew as well as the ability to generate differentiated cells. Oval cells are activated to proliferate and regenerate liver tissue when the liver damage is extensive and chronic, or if proliferation of hepatocytes is inhibited. Many factors are involved in regulating the proliferation and differentiation of HOC. This review focuses on the location, origin and regulatory mechanism of HOC.
出处
《国际消化病杂志》
CAS
2007年第5期361-363,共3页
International Journal of Digestive Diseases
关键词
肝卵圆细胞
调控
细胞因子
神经
氧化应激
Hepatic oval cell
Regulatory
Cytokine
Nerve,Oxidative stress
