摘要
目的探讨不同剂量和不同给药方式的阿托品对急性重症有机磷农药中毒(AOPP)的疗效和安全性。方法入选126例 AOPP 患者随机分为 A、B、C 3组,分别给予不同剂量和给药方式的阿托品。A 组首剂大剂量(5～10mg)静脉推注加静脉滴注法1～3 mg/min;B 组每次静脉推注10～25 mg;C 组每次静脉推注5～10 mg。B、C 两组均间隔5～10 min 给药1次,3组出现阿托品化后逐渐减量,直至停药。随访观察3组患者的阿托品中毒率、治愈率和死亡率。结果.A 组阿托品中毒率1.9%,治愈率98.1%,死亡率1.9%;B 组阿托品中毒率12.5%,治愈率93.7%,死亡率6.3%;C 组阿托品中毒率8.7%,治愈率95.7%,死亡率4.3%。结论持续静脉滴注阿托品抢救 AOPP 安全,疗效好,可避免阿托品中毒。
Objective To study the effects and security of different dose of atropine in different way in the treatment of patients with acute organophosphorus pesticides poisoning （AOPP）. Methods The 126 patients were randomly divided into three groups：A, B and C. Cure rate , death rate and atropine poisoning rate amount the three groups were compared. Results Cure rate（98. 10 % ） of group A was higher than group B （93.70 % ）. Death rate （ 1.90 % ） incidence of atropinism （ 1.90 % ） of group A are lower significantly than group B （ P 〈 0. 01 ）. And cure rate （95.7 % ） of group C was higher than group B , and death rate （4. 3 % ） incidence of atropinism （ 8.7 % ） of group C were lower significantly than group B （ P 〈 0. 05 ）. Conclusion It is more effective and safe effect by continuous intravenous atropine and avoid atropine poisoning.
出处
《临床急诊杂志》
CAS
2007年第5期269-270,共2页
Journal of Clinical Emergency
关键词
有机磷中毒
阿托品
疗效
安全性
Organophosphorus pesticide poisoning
Atropine
Efficacy
Security
