他汀类药物与缺血性脑血管病被引量：1

Statins and Ischemic Cerebrovascular Disease

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摘要他汀类药物能降低缺血性脑血管病的发病率,除降低血浆胆固醇外,可能尚涉及不依赖于胆固醇降低的非调脂抗动脉粥样硬化、稳定硬化斑块、抗炎症反应、抗血栓形成、改善内皮功能及上调脑组织内内皮型一氧化氮合酶的表达和活化等作用。他汀类药物的脑缺血保护机制目前尚未完全阐明,研究他汀类药物调脂以外的脑缺血保护作用有助于全面了解该类药在预防、治疗缺血性脑血管疾病中的作用。 Statins have pleiotropic effects in decreasing case fatality of ischemic cerebrovascular disease, lowering cholesterol in plasma, inhibiting artherosclemais independing on lipid regulation of lowering cholesterol, stabilizing the plague, inhibiting inflammatory reaction and thrombogenesis, improving the endothelial function, upregulating the activation and expression of nitricoxide synthase in brain tissue. Protective mechanism of statins for cerebral ischemia is not very clear, To study the protective effect of statins on cerebral ischemia besides its effect of lipid regulation is beneficial to understand overall effects of statins in preventing and treating ischemic cerebrovasculas disease.

作者陆景红周颖任明山

机构地区阜阳市人民医院神经内科安徽医科大学附属安徽省立医院神经内科

出处《医学综述》 2007年第21期1666-1668,共3页 Medical Recapitulate

基金安徽省阜阳市卫生局科研基金课题(06001)

关键词他汀类药物脑缺血脑血管意外内皮型一氧化氮合酶 Statins Cerebral ischemia Cerebral accident Endothelial nitric oxide synthase

分类号 R972 [医药卫生—药品] R743.3 [医药卫生—神经病学与精神病学]

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