摘要
目的评价采用布托啡诺配伍曲马多与单独应用布托啡诺或曲马多用于乳腺癌术后镇痛的安全性及有效性。方法60例乳腺癌术后病人,随机分为三组,A组为曲马多组,B组为布托啡诺组,C组为曲马多配伍布托啡诺组,术毕拔管前各组分别静注氯诺昔康16mg作为负荷量,接奥美电子泵行PCA治疗。结果术后1h、4h、8h,A、B组VAS评分明显高于C组(P<0.05),12h、24h、48hC组同A、B组VAS评分无明显差异(P>0.05)。A、B组恶心、呕吐、眩晕、嗜睡明显多于C组(P<0.05)。结论本研究三种方法中,C组具有镇痛效果好,不良反应少,是乳腺癌术后镇痛的好方法。
Objective To evaluate the effect and safety of analgesia with butorphanol combined tramadol and only use butorphanol or tramadol after breast cancer operations. Methods 60 cases with breast cancer were randomly divided into three groups. The tramadol, butorphanol and tramadol plus butorphanol were used in group A, B and C respectively. The patients in every group received postoperative analgesia with lornoxicam in a loading dose of 16 mg, and all groups received the electronic PCA pump therapy. Results The VAS score at the time point of 1,4,8 h after operation in group A and B were significantly higher than that in group C （P 〈 0.05）. There was no significant difference between group C with group A and B at postoperative 12 h,24 h,48 h （P〉 0.05）. The side-effects, such as nausea, vomiting, dizziness and somnolence in group A and B were significantly higher than those in group C （P〈0.05）. Conclusion In the three methods,The use of tramadol combined with butorphanol （group C） in patients-controlled analgesia after breast cancer operation has a better effect of analgesia and fewer adverse reaction
出处
《岭南现代临床外科》
2007年第5期358-359,364,共3页
Lingnan Modern Clinics in Surgery
关键词
布托啡诺
曲马多
镇痛
病人控制
乳腺癌
Butorphanol
Tramadol
Analgesia, Patient-controlled
Breast cancer
