摘要
目的检测过敏性紫癜(HSP)患儿血浆血栓调节蛋白(TM)、血管性假血友病因子(vWF)、基质金属蛋白酶-9(MMP-9)水平,探讨它们在HSP发病机制中的作用及与紫癜性肾炎(HSPN)的关系。方法2006-09—2007-02在青岛大学医学院附属烟台毓璜顶医院儿内科住院的HSP患儿46例,应用酶联免疫吸附试验(ELISA)检测HSP患儿急性期(46例)、缓解期(40例)及健康对照儿童(20例)血浆TM、vWF、MMP-9水平。结果HSP患儿急性期TM、vWF、MMP-9水平明显高于对照组(P均<0.01),也高于缓解组(P均<0.05)。MMP-9下降较缓慢,在恢复期仍显著高于对照组(P=0.01)。伴肾受累组vWF、MMP-9高于非肾受累组(P均<0.05),而TM在两组之间差异无显著性意义(P>0.05)。TM、vWF浓度之间成直线正相关,而TM、vWF分别与MMP-9之间相关性分析无统计学意义。结论血管内皮细胞及细胞外基质损伤在HSP的发病机制中起着重要的作用,血浆TM、vWF、MMP-9水平测定有助于了解病情活动及判断是否合并肾脏损害,动态测定有助于观察病情演变及指导治疗。
Objective To investigate the role of plasma thrombomodulin （ TM ） ,von willebrand factor （ vWF ） and matrix metalloproteinase-9 （ MMp-9 ） in children with Henoch-Schonlein purpura （ HSP ）. Methods The plasma concentrations of TM,vWF,MMP-9 were measured by enzyme-linked immunosorbent assay （ ELISA） method in 46 acute SHP patients, 40 recovery patients and 20 healthy controls. Results The plasma levels of TM,vWF,MMP-9 in acute phase were significantly higher than those in healthy controls（ P 〈0. 01 ） and higher than those during recovery period. The plasma levels of MMP-9 for the SHP patients dropped back slowly and their levels during recovery period were still higher than those in healthy controls （ P =0.01 ）. The plasma levels of TM,MMP-9 were higher in renal damage group than in non-renal damage group （ P 〈 0. 05 ）. whereas the plasma levels of TM had no significant difference between them （ P 〉 0. 05 ）. The plasma levels of TM showed positive correlation with the level of vWF. But The plasma levels of TM and vWF showed no correlation with the level of MMP-9. Conclusion The damage of vascular endothelium and extracellular matrix plays an important role in the pathological mechanism of HSP. The levels of plasma TM,vWF,MMP-9 may be used as indexes of the HSP activity and progression.
出处
《中国实用儿科杂志》
CSCD
北大核心
2007年第10期770-772,共3页
Chinese Journal of Practical Pediatrics
