摘要
目的:对产后42 d回访细菌性阴道病(bacterial vaginosis,BV)患者采用乳酸杆菌活菌制剂治疗,追踪观察治愈率、复发率,观察治疗效果。方法:对2012例产后42 d妇女常规筛查出BV患者103例为实验组,与对照组50例。实验组采用活性乳酸菌阴道胶囊2枚(0.25 g/枚),每日1次,阴道上药×10 d。对照组采用甲硝唑栓1枚,每口1次,阴道上药×10 d。结果:实验组与对照组的临床治愈率分别为92.23%(95/103)、84%(42/50),总有效率分别为95.15%(98/103)、92%(46/50),差异均无显著性意义(P>0.05);复发率分别为3.88%,34%,差异有显著性意义(P<0.05);两组治疗后阴道乳酸杆菌的检出率分别为96.12%、20.00%,差异有显著性意义(P<0.05)。阴道乳酸杆菌的检出数量与细菌性阴道病复发率之间存在负相关(R=-0.845,P=0.034)。结论:应用活性乳酸杆菌制剂治疗BV短期疗效与对照组组基本相同,但治疗后阴道乳酸杆菌的恢复程度明显优于对照组,复发率明显低于传统疗法。
Objective： To invesigate the curability,recurrent rate and curative effect of lactobacillus-based medicament to bacerial vaginosis （BV） of women after puerperium. Methods： 103 sufferers with BV were screened in 2012 women after puerperium, as experimental group, and selected 50 BV women as control group. Two pieces of lactobacillus-based drug （0.25 g/piece） were applied to the exper-imental group every day for 10 clays. One piece of metronidazole drag was used to the control group per day for 10 days. Results： The clinical curability in the two groups was 92.23% （95/103） ,84% （42/50） respectvely The total efficiency in the two groups was 95.15% （98/103）, 92% （46/50） respectively. There was no significant difference between the two groups. The recurrent rate in experimental and control groups was 3.88% and 34. 00% respectively. The detectable rate of lactobacillus in the experi-mental and control groups after the treatment was 96.12% and 20.00% respectively （P 〈 0. 051 ）. Negative correlation was shown between detectable rate of lactobacillus and recurrent rate （R = -0. 845, P = 0. 0341 ）. Conclusion ： The short - term curative effect of the lactobacillus-based drug is almost same with the result of control group. But the use of the lactobacillus-based drug never decreases the lactobacillus number opposite to the use of metronidazole, so that depresses the recurrent rate of the BV-reinfction.
出处
《河南医学研究》
CAS
2007年第3期236-238,共3页
Henan Medical Research
关键词
产褥期
产后随访
细菌性阴道病
乳酸杆菌
puerperium
postpartum follow-up
bacterial vaginosis
lactobacillus
