摘要
目的探讨发生药源性过敏性休克的特点和规律。方法检索中国生物医药文献数据库1996年～2006年医药类期刊报道的药源性过敏性休克病例,并进行统计、分析。结果抗微生物药物、中草药、生物制品的过敏性休克发生率及死亡率居前3位;静脉用药不良反应发生率最高,占69.34%;速发型过敏性休克比例最大,占82.70%;药源性过敏性休克与性别、年龄无关。结论用药前询问过敏史,严格用药指征,观察用药后的不良反应,确保用药安全。
Objective To probe the characteristic and regularity of drug-induced allergic shock. Methods The case reports of drug-induced allergic shock, published on Chinese medical periodicals during the period of 1996 to 2006, were collected and analysed. Results incidence rate and mortality of allergic shock induced by antimicrobials, Chinese herb medicine and biologicals occupied the front 3 places in sequence, and drugs for intravenous administration resulted in the highest rate （69.34%）. A large proportion of allergic shock was immediate type（82.70%）. Drug-induced allergic shock was ind, ependent of sex and age. Conclusion Allergic history should be taken in detail before the use, the indications of drug use strictly controlled and the ADRs observed so as to ensure the safe use of drugs.
出处
《中国药物警戒》
2007年第5期289-292,296,共5页
Chinese Journal of Pharmacovigilance
关键词
药源性过敏性休克
合理用药
药品不良反应
drug-induced allergic shock
rational use of drug
adverse drug reaction（ADR）
