摘要
采用单克隆抗preS_2RPHA法检测HBV所致各型肝炎的preS_2,检出率为:急肝86.6%、慢迁肝81.2%、慢活肝87.5%、肝硬化83.3%、肝癌80%、HBsAg携带者73.3%,健康人为0。此结果与国内文献报道相似。证明preS_2检出在HBsAg携带者中低于各型肝炎。preS_2检出与HBeAg阳性检出呈正相关。在慢肝中检出preS_2,提示preS_2可作为观察病毒复制和预后的指标之一。
Serum preS_2 were measured by monoclonal antibody R-PHA of anti-preS_2 in patients with several clinical types of hepatitis B.The positive rates of preS_2 in AH,CAH,CPH,CH,PHC,HC and healthy man were 86.6%,81.2%,87.5%,83.3%,80.0%,73.3% and 0% respectively;the highest were those of CAH and AH.The positive rates of HBeAg in preS_2 positive patients and preS_2 negative patients were 76.4% and 0% respecti- vely.These results revealed that there was a direct relationship between the positive rate of preS_2 and the positive rate of HBeAg.The positive rate of preS_2 in HBsAg carriers was lower than those of the several clinical types of hepatitis B.These results suggested that preS_2 test could be used as markers for evaluating the chronic evolution,HBV replication and the prognosis of hepatitis.
