摘要
目的：本试验旨在研究氟比洛芬酯在鼻腔手术术后镇痛的效果及不良反应。方法：选择ASAⅠ~Ⅱ级在全身麻醉下行鼻腔手术的患者60例,随机分成3组。Ⅰ组患者术前5分钟静脉缓慢注射氟比洛芬酯（1mg/Kg）;Ⅱ组于术后患者苏醒,拔除气管导管后缓注氟比洛芬酯（1mg/Kg）;Ⅲ组不注射氟比洛芬酯。分别观察术中的出血量,血糖的变化,及血小板的聚集功能,记录术后2、6、12小时的视觉模拟评分（VAS）,以及麻醉与镇痛相关的不良反应。结果：术中出血量Ⅰ组和Ⅲ组差异无显著性（P（0.05）。三组术前血糖差异无显著性（P〉0.05）,术后Ⅰ、Ⅱ组均低于Ⅲ组（P（0.05）,但Ⅰ、Ⅱ组术后差异无显著性（P〉0.05）。Ⅰ、Ⅱ组血小板聚集率术前和术后差异均无显著性（P〉0.05）。术后2、6小时VAS评分Ⅰ、Ⅱ组均低于Ⅲ组（P（0.05）,但Ⅰ、Ⅱ组无显著性差异（P〉0.05）。12小时VAS三组均无显著性差异（P（0.05）。在观察中均未发现相应的并发症。结论：研究结果提示,氟比洛芬酯可用于鼻部手术的术后镇痛。
To study the postoperative analgesia of flurbiprofen axetil in nasal operation and its side effects. Methods： 60 patients ASA Ⅰ
～Ⅱ undergoing nasal operation were randomly divided into three groups： group I ： flurbiprofen axetil（ 1 mg/Kg, iv） 5 min prior to the operation;group Ⅱ - flurbiprofen axetil （ 1 mg/Kg, iv） after the patients regain consciousness and extubation; group Ⅲ： without flurbiprofen axetil. Intraoperative blood loss, the influence on blood sugar（BS） and platelet aggregation function （PAF） were estimated. Postoperative visual analogue scores （VAS） and adverse effects were recorded at 2, 6, 12 hours after the operation. Results： There was no significant difference in blood loss between group I and group Ⅲ. There was also no significant difference in preoperative BS among three groups. The postoperative BS in group I , lI was significantly lower than that in group Ⅲ, but the difference of blood sugar was not significant between group I and group Ⅱ. There was also no significant difference in platelet aggregation function between group I and group Ⅱ. VAS in group I and group Ⅱ was no significantly differet, but they were significantly lower than that in group Ⅲ at 2 and 6 hours after operation. There was no significant difference in VAS 12 hours after operation. During the observation, there was no adverse effect in three groups. Conclusion. The postoperative analgesia of flurbiprofen axetil was safe and effective in patients undergoing nasal operation.
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2007年第5期269-271,共3页
Chinese Journal of Pain Medicine
关键词
氟比洛芬酯
鼻部手术
术后镇痛
Flurbiprofen axetil
Nasal operation
Postoperative analgesia
