摘要
对29例恶性组织细胞增生症(MH)的尸检材料,从病理形态、免疫组化及电镜超微结构三方面进行研究。发现MH病人胸腺萎缩,哈氏小体囊性变、钙化,提示病人伴有免疫功能缺陷。部分恶组细胞与α_1抗胰蛋白酶及溶菌酶反应,电镜下可见恶组细胞仍保持组织细胞的某些形态特征,支持恶组细胞起源于单核巨噬细胞系统的学说。赞成生前多部位反复骨髓穿刺检查,可能有助于提高生前诊断率。
Autopsy materials from 29 cases of MH were studied by routine pathologic,immunohistochemical and electron microscopic methods.Thymus atrophy,cystic changes and calcification of the Hassall Corpuscle were found. These findings indicate that immunodeficiency usually complicate MH. In the immunohistochemical study,most of the tumor cells showed positive reaction for α_1AT,and partially for Lysozyme.But,all of them were negative for Pan T and Pan B in MH of the intestine.Under electron microscope,normal histiocytes characterictics were retained in the malignant cells of various stages of MH.Based on these facts,it was most likely that the tumor cells of MH originated from the premature histiocytes of the mononuclear phagocytic system.
基金
广西卫生厅资助项目
关键词
恶性组织
细胞增生症
病理
免疫学
Malignant histiocytosis
Thymus
Immunodeficiency
Immunohistochemistry
Microscopic obseivation
