摘要
心肌纤维化是由心肌间质胶原过多蓄积引起,在病毒性心肌炎各期均不同程度地存在,尤其以恢复期与慢性期改变明显。心肌纤维化受多种因素调控,包括病毒直接损伤、转化生长因子-β1(TGF-β1)、肾素-血管紧张素-醛固酮系统、一氧化氮和内皮素、哺乳动物雷帕霉素靶蛋白(mTOR)等。临床表现缺乏特征性。病毒性心肌炎慢性期可行抗纤维化治疗。
Myocardial fibrosis is caused by the excessive accumulation of collagen. It can be found in all stages of viral myocarditis, especially in the recovery and chronic stage. The myocardial fibrosis is regulated by many factors including direct viral tissue damage and indirect damage caused by transforming growth factor [31 （TGF-[31）, renin-an- giotensin-aldosterone system, nitric oxide/endothelin, and mammalian target of rapamycin （roTOR） . There is a lack of specificity in the clinical manifestations of myocardial fibrosis. The anti-fibrosis therapy is necessary only in the chronic stage of viral myocarditis.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2007年第10期807-810,共4页
Journal of Clinical Pediatrics
关键词
心肌炎
病毒
心肌纤维化
诊断
治疗
myocarditis
virus
myocardial fibrosis
diagnosis
treatment
