摘要
一例13岁女孩面部和四肢为主反复出现红斑、丘疹、水疱样皮损9年,皮疹形态与牛痘水疱病相似(hydroa vacciniforme,HV)。在病情急性进展期,伴高热,体温39℃以上。皮肤科检查:面部水肿,面部和四肢较多的萎缩性圆形和椭网形痘疮样瘢痕,散在红斑、丘疹、坏死和结痂;四肢数个水肿性红色斑块,中心有圆形破溃面。组织学上,在真皮的血管和附属器周围,可见大量表达CD8异形淋巴细胞浸润,诊断CD8^+皮肤T细胞淋巴瘤。糖皮质激素和免疫抑制剂可使病情缓解,随诊至今,无系统受累情况。
A 13-year-old girl presented with a 9-year history of hydroa vacciniforme （ HV ）-like eruption, including erythema, papules and vesicles, mainly distributed at the face and extremities. A high fever （ 〉 39℃ ） developed at the progressive stage of this disease. Physical examination showed variously sized, round or oval, atrophic and variola-like scars along with scattered erythematous patches, papules, necrosis and crusts on the face and extremities. The face was edematous, and there were some edematous and erythematous plaques with a necrotic center on the legs and arms. Histological examination revealed a massive infiltration with atypical CD8^＋ lymphocytes around the vessels and appendages in dermis. A diagnosis of CD8^＋ cutaneous T-cell lymphoma （ CTCL ） was made. Glucocorticoid and immunosuppressants were effective in controlling the condition. Up to the time of the writing, there has not been any definite evidence of systemic involvement.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2007年第10期598-600,共3页
Chinese Journal of Dermatology
