摘要
目的：探讨影响局部晚期宫颈癌的预后因素及辅助化疗在子宫颈癌治疗中的价值。方法：2000年1月-2004年6月收治的ⅠB-ⅡB期宫颈癌患者共104例,接受手术及辅助放疗同时辅助化疗（A组）,与1996年6月-1999年12月在汕头大学医学院附属肿瘤医院仅接受手术和辅助放疗的51例宫颈癌患者（B组）比较,分析其预后不良因素,并比较两组患者生存率情况。结果：两组例数相差较大,但差异无统计学意义。B组盆腔复发率、远处转移率均高于A组,P值分别为0.019和0.041。A组生存率高于B组,χ^2=12.543,P=0.000。结论：根据患者预后不良因素,辅助化疗与手术、放疗结合的综合治疗能提高生存率,减少复发与转移。
OBJECTIVE：To explore the pertinent prognostic factors and the clinical value of adjuvant chemotherapy in patients with advanced cervical carcinoma. METHODS： The pertinent prognostic factors were retrospectively analysed and the survival rates were compared between 104 patients （as observation group, Group A） with clinical stage Ⅰ B- Ⅱ B cervical cancer who underwent multidisciplinary therapy （not only radical surgery and adjuvant radiotherapy but also adjuvant chemotherapy） from Jan 2000 to Jun 2004 and 51 patients （as control group, Group B） who only accepted surgery and adjuvant radiotherapy from Jun. 1996 to Dec. 1999. RESULTS： There was no significant difference in prognostic factors between the two groups, but the recurrence rate and distant metastasis rate were lower in Group A than those in Group B, P =0.019, P=0. 041. The survival rate was significantly higher in Group A than that in Group B （χ^2= 12. 543,P=0. 000）. CONCLUSIONS： A significant benefit of multidisciplinary therapy is proved in advanced cervical carcinoma patients according to the prognostic factors. The multidisciplinary therapy, including radical surgery, adjuvant radiotherapy and adjuvant chemotherapy can be used in the patients with poor prognostic factor.
出处
《中华肿瘤防治杂志》
CAS
2007年第20期1577-1579,共3页
Chinese Journal of Cancer Prevention and Treatment
