摘要
目的：探过尿毒症瘙庠的原因及其防治对策。方法：观察２５例尿毒症患者皮肤肥大细胞增殖情况，以及血清ＰＴＨ、ＢＵＮ、Ｃｒ、Ｃａ、Ｐ、ＡＫＰ及ＩｇＥ水平。结果：本组尿毒症瘙痒发生率６４％，瘙痒组Ｓｃｒ、肥大细胞数和血清ＰＴＨ均＞无瘙痒组；肥大细胞数与血清ＰＴＨ呈正相关；两组血清Ｃａ、Ｐ、ＡＫＰ、ＩｇＥ差异不显著。结论：①皮肤肥大细胞数增多和血清ＰＴＨ水平增高可能是尿毒症瘙痒的原因之一；②充分透析和使用高通透性膜透析或滤过，是缓解瘙痒症状的有效措施之一。
OBJECTIVE To investigate the possible mechanisms of uremic pruritus in patients with chronic renal failure. METHODOLOGY The proliferation of skin mast cells obtained by skin biopsies were observed in 25 patients underwent maintenance hemodialysis. The serum levels of PTH, BUN, Cr, Ca, P , AKP and IgE were measured in those patients. RESULTS It was found that the incidence of pruritus was 64% in this group of patients. There was a strong correlation between the number of mast cells in skin and the serum PTH level in patients with pruritus. The levels of serum creatinine and the number of mast cells were significantly higher in patients with pruritus than those without pruritus, while there were no differences in the serum levels of Ca, P, AKP and IgE between two groups. CONCLUSION The increased number of mast cells and the high level of serum PTH may be responsible for the pruritus in patients with uremia. Effective dialysis and hemofiltration or dialysis with high permeability membrane might alleviate the pruritus.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1997年第1期39-42,共4页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
尿毒症
瘙痒
临床研究
pruritus mast cells parathormone(PTH)
