摘要
目的检测急性视神经炎(acute optic neuritis,AON)患者血清促炎细胞因子的表达水平,探讨这些细胞因子是否在AON演进为多发性硬化(multiple sclerosis,MS)中具有临床预测价值。方法60例确诊的AON患者,应用ELISA方法检测血清促炎细胞因子IL12、IFNγ以及TNFα的表达。分别于发病后6个月和12个月对患者进行两次随访和综合评估,探讨IL12、IFNγ以及TNFα在AON向MS演进的预测价值。结果AON血清IL12、IFNγ以及TNFα的表达显著增高(P<0.05);其中头部MRI异常组和脑脊液异常组的血清促炎细胞因子表达水平,均高于头部MRI正常组(P<0.05)和脑脊液正常组(P<0.05)。随访6个月和12个月时,分别有6例和11例AON患者演进为确定的/可能的MS。演进组患者AON急性期血清IL12、IFNγ以及TNFα表达水平,显著高于非演进组(P<0.05)。结论检测AON患者血清促炎细胞因子IL12、IFNγ以及TNFα,可能对AON是否演进为MS具有一定的临床预测价值。
Objective To study the predictive value of expression of proinflammatory cytokines in sera in patients with acute optic neuritis （AON）. Method Prospective method was used to research,60 patients of AON were accepted. They were examined the levels of three vital proinflammatory cytokines（ILA2 ,IFNγ and TNFα） in sera by the means of EI.ISA. Patients were followed up after 6 and 12 months. The predictive value were analyzed by the comparison between the subgroups which would like to develop into definite or probable Multiple Sclerosis （MS） or not. Result The level of all cytokines in AON were significantly higher than healthy controls（P〈0.05）. The subgroup with abnormal MRI of head and/or CSF showed higher expression than normal subgroup （P〈0.05）. There were 6 and 11 patients who were developing into definite/probable MS after 6 and 12 months follow up respectively. The level of eytokines were significantly higher those who developed than the others （P〈0.05）. Conclusion Proinflammatory cytokines levels in sera were valuable to predict the prognosis and follow-up for AON.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2007年第4期419-421,共3页
Journal of Apoplexy and Nervous Diseases
基金
黑龙江省攻关国际合作项目(No.WC05C04)
哈尔滨市青年科技创新人员专项资金项目(No.2005AFQXJ069)
关键词
急性视神经炎
多发性硬化
促炎细胞因子
随访
Acute optic neuritis
Multiple sclerosis
Proinflammatory cytokines follow up
