摘要
目的分析临床常见假丝酵母菌属对常用抗真菌药物的耐药性。方法采用法国生物梅里埃公司提供的ATB FUNGS 2试验板条,测定243株临床常见假丝酵母菌属的最低抑菌浓度(MIC)值。结果243株假丝酵母菌属以白色假丝酵母菌为主,占64.6%,其他依次为光滑假丝酵母菌(14.4%)、热带假丝酵母菌(11.1%)、近平滑假丝酵母菌(5.8%)、克柔假丝酵母菌(4.1%);上述5种常见假丝酵母菌对5-氟胞嘧啶、两性霉素B、氟康唑和伊曲康唑4种抗真菌药物均产生了耐药性,其中克柔假丝酵母菌耐药率较高,对4种抗真菌药物的耐药率分别为20.0%、50.0%、30.0%和40.0%;上述5种常见假丝酵母菌对伊曲康唑耐药率均较对氟康唑高。结论临床常见假丝酵母菌属对常用抗真菌药物已具有一定的耐药性,应加强监测与控制。
OBJECTIVE To evaluate the drug resistance METHODS The minimal inhibitory concentration （MIC） Fungus drug susceptibity plate provided by Bio-Merieux, of Candida isolated from patients specimen in clinic. test to 243 Candida strains was performed using ATBRESULTS The most popular species of Candida in clinic was Candida albicans （64.6%）, C. glabrata （14.4%） , C. tropicalis （11.1%） ,C. para psilosis （5.8%）and C. krusei （4. 1%）. There was a certain resistance to the 4 kinds of common antifungals including flucytosine, amphotericin B, fluconazole and itraconazole. The resistance status of C. krusei was the most serious, Its resistance rate to 4 kinds of antifungals was 20. 0%, 50. 0%, 30. 0% and 40. 0%, respectively. The drug resistance rate of 5 species of Candida to itraconazole was higher than that to fluconazole. CONCLUSIONS The commonly encountered Candida produce particular resistance to common antifungals, and it is very necessary to detect and control them.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2007年第9期1171-1173,共3页
Chinese Journal of Nosocomiology
关键词
假丝酵母菌属
最低抑菌浓度
耐药性
Candida
Minimal inhibitory concentration
Drug resistance
